Activity
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Honored to share that I’ve received a Spring 2026 Research Grant from The Glaucoma Foundation! Thank you so much for supporting our project. Deeply…
Honored to share that I’ve received a Spring 2026 Research Grant from The Glaucoma Foundation! Thank you so much for supporting our project. Deeply…
Liked by Min Wan
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Join our awesome AIRx dynamic team at Takeda poised to deliver differentiated medicines to patients!
Join our awesome AIRx dynamic team at Takeda poised to deliver differentiated medicines to patients!
Liked by Min Wan
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Congratulations to Ainslie Little on joining ProFound Therapeutics as COO! Wishing you every success as you help lead ProFound through this exciting…
Congratulations to Ainslie Little on joining ProFound Therapeutics as COO! Wishing you every success as you help lead ProFound through this exciting…
Liked by Min Wan
Experience
Education
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Fudan University
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Established a mouse model ectopically expressing hTSC1 in skeletal muscle, and investigated the molecular mechanism of TSC induced muscle atrophy.
Constructed a human cDNA library for gene-function screens in Drosophila. -
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Publications
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Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP
Cell Metabolism
See publicationPapazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs
ER, Rabinowitz JD, Lazar MA. Physiological Suppression of Lipotoxic Liver Damage by
Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metabolism 2016 Dec; 24(6): 863-874 -
Phenotyping hepatocellular metabolism using uniformly labeled carbon-13 molecular probes and LC-HRMS stable isotope tracing
Analytical Biochemistry
See publicationMeissen JK, Pirman DA, Wan M, Miller E, Jatkar A, Miller RA, Steenwyk RC, Blatnik M. Phenotyping
hepatocellular metabolism using uniformly labeled carbon-13 molecular probes and LC-HRMS stable
isotope tracing. Anal. Biochem. 2016 Sep; 508: 129-137 -
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
Nature Communications
See publicationPatel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M,
Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, Birnbaum MJ, Sutherland C,
Sakamoto K. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in
the liver. Nat Commun. 2014 Aug; 5:4535 -
A Noncanonical, GSK3-Independent Pathway Controls Postprandial Hepatic Glycogen Deposition
Cell Metabolism
See publicationWan M, Leavens KF, Hunter RW, Koren S, von Wilamowitz-Moellendorff A, Lu M, Satapati S, Chu Q, Sakamoto K, Burgess SC, Birnbaum MJ. Cell Metabolism 2013 July: 18(1): 99-105
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Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
Nature Medicine
See publicationLu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR, Birnbaum MJ. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nature Medicine 2012 March; 18(3): 388-395
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Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity
Molecular and Cellular Biology
See publicationWan M, Easton RM, Gleason CE, Monks BR, Ueki K, Kahn CR, Birnbaum MJ. Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Mol. Cell. Biol. 2012 Jan; 32(1): 96-106
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Of Mice and Men: Not ExAKTly the Same?
Cell Metabolism
See publicationWan M, Birnbaum MJ. Of Mice and Men: Not ExAKTly the Same? Cell Metabolism 2011 Dec; 14(6): 722-723
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Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c
Cell Metabolism
See publicationWan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM,
Birnbaum MJ. Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of
the Transcription Factors FoxA2, FoxO1, and SREBP1c. Cell Metabolism 2011 Oct; 14(4):516-527 -
The role of FOXO in the regulation of metabolism.
Current Diabetes Report
See publicationGross DN, Wan M, Birnbaum MJ. The role of FOXO in the regulation of metabolism. Curr. Diab. Rep. 2009 Jun;9(3):208-14
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Muscle atrophy in transgenic mice expressing a human TSC1 transgene.
FEBS Letters
See publicationWan M, Wu X, Guan K-L, Han M, Zhuang Y, Xu T. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett. (2006), Vol. 580(24): 5621-7
More activity by Min
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I am hiring! This is the second Principal Scientist position specifically focused on Obesity and it’s comorbadities. We’re expanding our Obesity…
I am hiring! This is the second Principal Scientist position specifically focused on Obesity and it’s comorbadities. We’re expanding our Obesity…
Liked by Min Wan
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Antibodies have changed medicine, but we believe they have not yet reached their full therapeutic potential. At Metaphore Biotechnologies, we are…
Antibodies have changed medicine, but we believe they have not yet reached their full therapeutic potential. At Metaphore Biotechnologies, we are…
Liked by Min Wan
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A few weeks ago, I wrapped up my six-month co-op as a Mechanism of Action Research Co-op with the Metabolic Disease team at Pioneering…
A few weeks ago, I wrapped up my six-month co-op as a Mechanism of Action Research Co-op with the Metabolic Disease team at Pioneering…
Liked by Min Wan
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We’re excited to share that the results from our pivotal Phase 3 trial in acquired #hypothalamic #obesity have been published in The New England…
We’re excited to share that the results from our pivotal Phase 3 trial in acquired #hypothalamic #obesity have been published in The New England…
Liked by Min Wan
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We are excited to share that we are collaborating with Eli Lilly and Company's #TuneLab. By combining our AND™ Platform, which has advanced…
We are excited to share that we are collaborating with Eli Lilly and Company's #TuneLab. By combining our AND™ Platform, which has advanced…
Liked by Min Wan
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Excited to see this work out! Several years in the making diving deep into the insulin-dependent mechanisms, governing glucose metabolism. Adipocytes…
Excited to see this work out! Several years in the making diving deep into the insulin-dependent mechanisms, governing glucose metabolism. Adipocytes…
Liked by Min Wan
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I’m excited and deeply honored to share that I’ve stepped into the role of Vice President and Head of Obesity Discovery at Pfizer. Having spent much…
I’m excited and deeply honored to share that I’ve stepped into the role of Vice President and Head of Obesity Discovery at Pfizer. Having spent much…
Liked by Min Wan
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Great opportunity at Pfizer to contribute to our growing obesity franchise, advancing innovative therapies across cardiometabolic disease.
Great opportunity at Pfizer to contribute to our growing obesity franchise, advancing innovative therapies across cardiometabolic disease.
Liked by Min Wan
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Last month, I made the decision to transition from my role at Pfizer to pursue the next chapter of my professional journey. Over a decade ago, I…
Last month, I made the decision to transition from my role at Pfizer to pursue the next chapter of my professional journey. Over a decade ago, I…
Liked by Min Wan
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It’s been an incredible ride to see this molecule make it to phase 3 when it was in the labs just 4 years ago!
It’s been an incredible ride to see this molecule make it to phase 3 when it was in the labs just 4 years ago!
Liked by Min Wan
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Excited to see this collaboration between Boehringer Ingelheim and Immunai. Having spent several years leading research at Boehringer Ingelheim…
Excited to see this collaboration between Boehringer Ingelheim and Immunai. Having spent several years leading research at Boehringer Ingelheim…
Liked by Min Wan
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