Stämm

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Nature delivers oxygen to billions of cells without a single bubble, but bioprocessing still relies on turbulence to do the same job. That gap is what the HTB wants to close, and it's what this series unpacks. Anatomy of a Bioprocessor brings together the team behind a continuous, bubble-free, laminar-flow bioprocessor layer by layer: → Juan Martin Cabaleiro on why stirred tanks stress cells, and the biological insight behind the design   → Leandro Leonardo on laminar flow and how a gyroid geometry packs more than 2 m² of surface per liter into a 50 mL cartridge   → Emiliano Jan on autonomous control and traceability logged to the last operation   → Maia Ludmila Budziñski on what a bubble-free environment changes for the cells   → Luciana Baldoni on the materials a cell lives in for 30 days The thread running through all of it: laminar flow doesn't have to be a trade-off against productivity, on the contrary. If you couldn’t come see the HTB run live at BIO International Convention 2026 in San Diego, watch the full explanation here. Learn more at stamm.bio

Four days at BIO 2026 are a wrap, and the HTB ran the whole way through. We'll definitely remember the conversations. Process development leads who stopped to watch the flip cycle and stayed to talk about their own bottlenecks; CDMOs sizing up what continuous, bubble-free bioprocessing could do for their pipelines; Cell therapy and biologics teams asking the kind of hard, specific questions that turn a booth chat into a real partnership. San Diego gave us the room to show this technology to the people it was built for, and they showed up. Thank you to Jean-Christophe Quillet, Faith Wallace-Gadsden, Agustina Thibaud Poretti, and Juan Martin Cabaleiro for running demo after demo, day after day. And thank you to everyone at Stämm, the team in Buenos Aires who built this, and everyone who got it onto a bench in San Diego. Finally, to BIO and everyone who came by Booth 5735: thank you. The conversations start here, but they don't end here. We'll be following up with every one of you. Last report from San Diego, Booth 5735. See you next year. #BIO2026 #Biomanufacturing #Bioprocessing

San Diego acaba de reunir a más de 20.000 de las personas que definen hacia dónde va la biomanufactura y Stämm fue a BIO 2026 a poner frente a ellas un bioprocesador laminar, continuo y libre de burbujas. "Estamos muy orgullosos de poder mostrar nuestra tecnología al mundo y representar a Argentina en la cancha de la biotecnología", señaló desde San Diego nuestro CTO, Juan Martin Cabaleiro. Un orgullo haber representado al deep tech argentino en el escenario global de la biotecnología y más todavía las conversaciones que el HTB abrió en el Booth #5735 respecto al futuro de la producción de biológicos. Gracias a la Cámara Argentina de Biotecnología y a PromArgentina por construir el pabellón que nos llevó hasta ahí y nos trajo tantas charlas y acuerdos a futuro.

At Booth 5735, Juan Martin Cabaleiro, PhD (our CTO) is running the HTB live, walking visitors through a full demo from cold start to continuous perfusion. It goes like this. The system has three parts: a Control Unit that coordinates everything from one screen, a Production Unit holding the BFB cartridge where cells live, and a Formulation Unit that prepares media and feeds. Juanma starts the flip cycle, the cartridge rotates 360° in each direction to keep cells evenly fed without any impeller. Open the casing mid-run and a safety interlock halts rotation automatically; close it and the cycle resumes on its own. Then perfusion: fresh medium enters in a smooth, bubble-free laminar stream while spent medium leaves at the same rate. The formulator delivers a pH-modifying reagent and the medium shifts from yellow to blue in real time, a visible confirmation of what the sensors are already reading on the dashboard. Dissolved oxygen, pH, CO₂, temperature are shown live from one screen. The design specs behind it: more than 2 m² of culture surface per liter, up to three independent experiments, continuous runs of up to 30 days. It's a Research Use Only platform built for R&D: bioprocess development, pre-clinical work designed with a path to GMP in mind. Come see the full walkthrough at the booth. Today's the last day! Book a demo (find the link in the comments below). San Diego | Booth 5735 | June 22–25 #BIO2026 #Biomanufacturing #Bioprocessing

At Booth 5735, Juan Martín Cabaleiro, PhD (our CTO) is running the HTB live, walking visitors through a full demo from cold start to continuous perfusion. It goes like this. The system has three parts: a Control Unit that coordinates everything from one screen, a Production Unit holding the BFB cartridge where cells live, and a Formulation Unit that prepares media and feeds. Juanma starts the flip cycle, the cartridge rotates 360° in each direction to keep cells evenly fed without any impeller. Open the casing mid-run and a safety interlock halts rotation automatically; close it and the cycle resumes on its own. Then perfusion: fresh medium enters in a smooth, bubble-free laminar stream while spent medium leaves at the same rate. The formulator delivers a pH-modifying reagent and the medium shifts from yellow to blue in real time, a visible confirmation of what the sensors are already reading on the dashboard. Dissolved oxygen, pH, CO₂, temperature are shown live from one screen. The design specs behind it: more than 2 m² of culture surface per liter, up to three independent experiments, continuous runs of up to 30 days. It's a Research Use Only platform built for R&D: bioprocess development, pre-clinical work designed with a path to GMP in mind. Come see the full walkthrough at the booth. Today's the last day! Book a demo (link in the comments below) San Diego | Booth 5735 | June 22–25 #BIO2026 #Biomanufacturing #Bioprocessing

Five years of mechanical engineering, machine learning, and a team in Buenos Aires went into the machine running behind Jean-Christophe Quillet at BIO 2026. Bubble-free laminar flow gives cells gentle conditions, and the gyroid geometry gives them room to grow: more than two square meters of surface per liter of volume. A single 250 mL cartridge can stand in for dozens of flasks. In our internal runs we've seen higher cell density, process transfer simplified several times over, and specific productivity climb well above the original process. The machine was built to support that: more than three production units running at once, continuous, batch, or any mix you want, with the flexibility to optimize your process however it needs to run. We took the long way to get here, studying how vascular systems feed every form of life and turning that into hardware. The goal was and still is to democratize manufacturing and simplify processes. That's why we're in San Diego this week, in front of the people who can put this to work: CDMOs, biopharma, innovators in cell therapy and antibody production. Come see it run. San Diego | Booth 5735 | June 22–25 #BIO2026 #Biomanufacturing #Bioprocessing

BIO International Convention 2026 is live in San Diego, and the HTB is on the floor with us. Juan Martin Cabaleiro, Faith Wallace-Gadsden, Jean-Christophe Quillet, and Agustina Thibaud Poretti are running the first public demos of the HTB, our High-Throughput Bioprocessor, right at the booth. Bubble-free laminar flow. No impellers, no spargers, no shear damage to your cells. Continuous harvesting. Running on a benchtop, in front of you. The booth is open. Book a demo (link in the comments) or come directly to watch it run and ask the hard questions. San Diego | Booth 5735 | June 22–25 #BIO2026 #Biomanufacturing #Bioprocessing

Turbulence is a known tax in most bioprocessing today. Stirred-tank bioreactors spin an impeller and push gas through a sparger to move oxygen and nutrients. That works for mixing, but also generates shear, bubble rupture, and foam that sensitive cells pay for, which is why antifoam agents and shear protectants became standard. Our CTO Juan Martin Cabaleiro, opens the series with the question that started everything: living organisms deliver oxygen to billions of cells without turbulence, so why don't bioreactors? See our HTB live at BIO2026 in San Diego, June 22–25. Booth #5735 Book a Demo: https://lnkd.in/dq5Sj3yT #BIO2026 #Biomanufacturing #Bioprocessing #continuousbiomanufacturing