CORE Diagnostics

At CORE Diagnostics, we believe that "Kidney Health for All" requires more than just awareness—it requires access to advanced testing. From monitoring creatinine levels to complex histopathology or advanced genomic testing, we bring gold-standard diagnostics to your doorstep. We provide the clarity you need to take charge of your renal health. Because a healthier tomorrow starts with an accurate diagnosis today. Did you know? 1 in 10 adults worldwide lives with kidney disease. Early intervention can slow progression and save lives. Your health is at the CORE of everything we do. 💚 #PrecisionMedicine #KidneyAwareness #HealthTech #COREDiagnostics #WKD2026

Her Power. Her Strength. Her Future. This International Women’s Day, we aren’t just celebrating milestones—we are advocating for the foundation that makes them possible: Health. Empowered women change the world, but empowerment starts with well-being. At CORE Diagnostics, we believe that providing women with precise, timely, and advanced diagnostic insights is the greatest way to secure their future. Today, let's commit to making self-care a priority, not an afterthought. Happy International Women’s Day! 🌸 Metropolis Healthcare #COREDiagnostics #Metropolis #WomensDay #InternationalWomensDay #WomenHealth #Empowerment #Pathology

CORE Diagnostics x SRMIST We are thrilled to announce that CORE Diagnostics has officially signed a Memorandum of Understanding (MoU) with SRM Institute of Science and Technology (SRMIST). This partnership marks a significant milestone in our mission to advance precision healthcare. By bridging the gap between industry expertise and academic research, we are set to accelerate innovation in genetic diagnostics and cancer research while nurturing the next generation of healthcare professionals. A huge thank you to the leadership and faculty from both organizations for making this collaboration possible. We look forward to creating meaningful impact through joint research initiatives, internships, and expert engagement. SRM IST Chennai Metropolis Healthcare CORE Diagnostics Surendran Chemmenkotil Dr Kirti Chadha Avadhut Joshi Mohan Menon Dr. Nilanju Sarma Dinesh Chauhan Shivani Sharma Kanika Jaggi Dr Mallika Dixit Dr. Ankita Jaiswal Govil Rahul Katara Brinderjit Buttar Ph.D Dr Priya Yadav Aditi Aggarwal Ruchi Bhajeewala Ashish Thakur Ashish Singhal Sachinkumar Pardeshi Sagar Samrat Mohanty PhD #SRMIST #CoreDiagnostics #MoUSigning #AcademicPartnership #IndustryAcademia #HealthcareInnovation #PrecisionMedicine #CancerResearch #Genomics #GeneticDiagnostics #Biotechnology #ResearchExcellence #HigherEducation #FutureReady #Innovation

Shaping the Future of Clinical Genomics in Women & Child Health We are honored to introduce our distinguished Advisory Board for the upcoming Centre of Genomics Advisory Discussion on 7th February — a strategic forum bringing together leading clinicians and experts to advance the integration of genomics into everyday clinical practice. As genomics rapidly transforms prenatal screening, reproductive medicine, and early disease detection, the need for clinically relevant, interpretable, and outcome-driven diagnostics has never been greater. This meeting is designed to enable expert-led dialogue on strengthening diagnostic pathways, enhancing reporting standards, and aligning genomic innovations with real-world patient care. The session will focus on fostering a collaborative, clinician-led approach to: • Improving the clinical utility of genomic testing • Bridging gaps between phenotype and genotype for more precise decision-making • Enhancing diagnostic workflows across prenatal and postnatal care • Supporting personalized treatment strategies in women and child health Guided by the insights of our Advisory Board, this initiative marks an important step toward building a robust genomics ecosystem that is accessible, evidence-based, and practice-oriented. We look forward to a powerful exchange of knowledge that will help redefine the future of precision medicine. DR. Chander Lulla Nitin Pai-Dhungat Dr Seeru Garg Dr. Anup Rawool Dr Sunita Tandulwadkar veena shinde #CentreOfGenomics #WomenAndChildHealth #ClinicalGenomics #PrecisionMedicine #PrenatalCare #MedicalInnovation #HealthcareLeadership

On #WorldCancerDay2026, we embrace the global theme: United by Unique. Our mission is to provide the clarity needed for personalized oncology — ✅ Early Detection saves lives. ✅ Advanced Genomics guides treatment. ✅ Compassion fuels the journey. Today, we stand with the survivors, the fighters, and the families. Together, we are #UnitedByUnique. Let’s close the care gap through the power of personalized diagnostics. 💡 Let’s lead the charge in making precision care the standard, not the exception.💡 #COREDiagnostics #Metropolis #CenterofGenomics #WorldCancerDay2026 #PrecisionMedicine #Oncology #NGS #MolecularPathology #LiquidBiopsy #HealthTech #UnitedByUnique #ClinicalExcellence

Love your body enough to listen. Care for it enough to check. This World Cancer Day, choose early detection. Choose prevention. Book your cancer screening today: https://lnkd.in/dfcRA__Z #MetropolisHealthcare #WorldCancerDay #ItGoodToBeSure [Metropolis Healthcare, Preventive Health, Cancer, World Cancer Day, Health Checkup]

#Fridayfindings #Caseoftheweek Bone Marrow Aspiration, Biopsy & Immunohistochemistry As hematopathologists, we occasionally encounter cases that remind us of the biological complexity of the bone marrow microenvironment. I would like to share a recent case highlighting the coexistence of Myeloproliferative Neoplasm (MPN) and Monoclonal Gammopathy of Undetermined Significance (MGUS) detected on bone marrow evaluation. 🧪 Clinical Context An elderly patient presented with persistent thrombocytosis and mild anemia. Serum protein electrophoresis revealed a low-level monoclonal spike, prompting a comprehensive bone marrow workup. 🔬 Bone Marrow Aspiration Findings ·       Hypercellular marrow for age ·       Marked megakaryocytic proliferation with clustering ·       Megakaryocytes showing atypical forms consistent with a myeloproliferative neoplasm ·       Plasma cells mildly increased (~5–7%), morphologically mature 🧬 Bone Marrow Biopsy Findings ·       Hypercellular marrow with preserved trilineage hematopoiesis ·       Increased and atypical megakaryocytes forming loose clusters ·       No significant fibrosis (reticulin stain: MF-0/1) ·       Interstitial increase in plasma cells without sheets or nodules 🧫 Immunohistochemistry ·       CD61/CD42b: Highlighted increased megakaryocytes ·       CD138: Plasma cells ~5–7% ·       Kappa/Lambda: Light chain restriction (lambda predominant) ·       CD34: No increase in blasts 🧾 Integrated Interpretation The overall findings were consistent with: ·       Myeloproliferative Neoplasm (likely Essential Thrombocythemia) ·       Coexistent MGUS This case underscores the importance of systematic marrow evaluation and immunohistochemistry in identifying dual hematologic pathologies, which may have distinct prognostic and therapeutic implications. 📌 Take-home Message The coexistence of MPN and MGUS, though uncommon, is a recognized entity and emphasizes the need for careful morphologic assessment and clinicopathologic correlation. Always fascinating how the bone marrow can tell more than one story at a time. Curated by: Dr.SHRUTI SANGWAN , Dr. Ankita Jaiswal Govil Shivani Sharma, Dr Mallika Dixit Dr. Ankita Jaiswal Govil Rahul Katara Dr.SHRUTI SANGWAN Dr. Puja Khanna Dr. Manisha Panda Dr. Gargy Gupta Vipra Malik Vedanti Newaskar Aditi Aggarwal Dr. Menka Sharma Sanjay Kumar Ph.D. Pawan Kirtani Nikhil Singh @samriti Arora Dinesh Chauhan #Hematopathology #BoneMarrowBiopsy #MyeloproliferativeNeoplasm #MGUS #Immunohistochemistry #PathologyEducation #DiagnosticPathology

📌 Interesting Cytogenetic Profile in Chronic Myeloid Leukemia (CML) Chronic myeloid leukemia (CML) is characterized by the chromosomal translocation t(9;22)(q34.1;q11.2) resulting in the formation of the Philadelphia (Ph) chromosome. Significant improvement in prognosis and survival rate has been seen after the introduction of tyrosine kinase inhibitors (TKI) in the treatment protocol. But over the years of treatment, additional cytogenetic abnormalities (ACA) are known to crop up in Ph+ cells due to cytogenetic evolution. The most common additional abnormalities include trisomy 8 and trisomy 19 and extra copy of Ph chromosome and i(17) (q10). The evolution of these abnormalities in Ph+ cells predicts a poorer response to TKIs and a higher risk of progression. 📃 Case highlights: · Presence of t(9;22) translocation (Philadelphia chromosome) · Extra Philadelphia chromosome (Derivative 22 due ot 9-9;22) · Isochromosome 17q [i(17q)] 🎯 Why this matters: · An extra Ph chromosome indicates clonal evolution and is commonly associated with accelerated or blast phase CML. · Isochromosome 17q results in loss of 17p (TP53 locus) and gain of 17q, a change linked to genomic instability, disease progression, and poorer prognosis. · These abnormalities often suggest resistance to therapy and the need for closer monitoring or treatment modification. 🧠 Take-home message: Comprehensive cytogenetic and molecular analysis is essential in CML—not only at diagnosis but also during follow-up—to detect clonal evolution early and guide risk-adapted management. 📰 Educational reminder: CML is not static; cytogenetic evolution can significantly impact outcomes. Curator - Sonika Sharma Shivani Sharma, Dr Mallika Dixit Dr. Ankita Jaiswal Govil Rahul Katara Dr.SHRUTI SANGWAN Dr. Puja Khanna Dr. Manisha Panda Dr. Gargy Gupta Vipra Malik Vedanti Newaskar Aditi Aggarwal Dr. Menka Sharma Sanjay Kumar Ph.D. Pawan Kirtani Nikhil Singh @samriti Arora Dinesh Chauhan #Cytogenetics #Hematopathology #ChronicMyeloidLeukemia #PhiladelphiaChromosome #ClonalEvolution #CancerGenetics #LeukemiaResearch #Isochromosome17q #MedicalCaseStudy #PrecisionMedicine #Hematology #Pathology #MolecularDiagnostics #OncologyEducation #ClinicalGenetics #MedEd #LabMedicine #CancerCare #HematologyBoardReview

📰 Case Summary: Systemic Amyloidosis in a Complex Clinical Scenario This case highlights the need to consider infiltrative disorders like amyloidosis in patients with unexplained multisystem symptoms. 🎯Clinical Background · Presentation: A 2-year history of leg swelling and significant proteinuria. · Key Event: Spontaneous splenic rupture in Feb 2025, requiring splenectomy. 🧪Key Investigations · CBC: 12.6 g/dL / 9,970/µL / 334 × 10⁹/L · Urine Protein:Creatinine Ratio: 8.48 (heavy proteinuria) · Serum Amyloid A: Negative (argues against AA amyloidosis) · Serum Protein Electrophoresis: No M-band · Serum Free Light Chains: o  Kappa 710 mg/L; Lambda 113 mg/L o  κ/λ ratio 6.28 → supports a monoclonal light-chain process even without detectable M-protein 🧪Tissue Diagnosis · Kidney Biopsy: Confirmed amyloid deposition. · Bone Marrow: o  Aspirate: Hypercellular marrow with 8–10% plasma cells. o  Biopsy: Plasmacytosis with Congo red–positive amyloid showing apple-green birefringence. 📚 Take-Home Message: Why Bone Marrow Biopsy Matters In suspected AL amyloidosis, bone marrow biopsy is indispensable—even when serum studies appear nondiagnostic. It provides: · Direct evidence of a plasma-cell clone (often small and easily missed on routine tests). · Tissue confirmation of amyloid, establishing the diagnosis with certainty. · Critical information for staging and treatment planning, linking the monoclonal process to systemic involvement. 📌Essential point: A bone marrow biopsy can be the decisive test that converts ambiguous lab findings into a definitive diagnosis of AL amyloidosis—especially when the monoclonal protein burden is low or invisible on electrophoresis. Curator - Dr. Menka Sharma, Dr. Ankita Jaiswal Govil Shivani Sharma, Dr Mallika Dixit Dr. Ankita Jaiswal Govil Rahul Katara Dr.SHRUTI SANGWAN Dr. Puja Khanna Dr. Manisha Panda Dr. Gargy Gupta Vipra Malik Vedanti Newaskar Aditi Aggarwal Dr. Menka Sharma Sanjay Kumar Ph.D. Pawan Kirtani Nikhil Singh @samriti Arora Dinesh Chauhan #COREDiagnostics #Metropolis #SystemicAmyloidosis #ALAmyloidosis #InfiltrativeDisorders #NephroticSyndrome #Proteinuria #LightChainDisease #MonoclonalGammopathy #PlasmaCellDyscrasia #Hematology #Nephrology #KidneyBiopsy #BoneMarrowBiopsy #CongoRed #SplenicRupture #MedicalDiagnosis #RareDisease #ClinicalCase #InternalMedicine #DiagnosticChallenge #MedicalEducation